Rectal suppositories API-NORM^® NЕО

• Propolis (ekstrakt)
• Hypericum (ekstrakt)
• Comfrey (ekstrakt)
• Pink periwinkle (extract)
• Celandine (extract)
• Ascorbic acid

• Beeswax (natural)
• Solid fat
• Polyethylene oxide
• Dimethyl sulfoxide
• Polysorbate

Anti-inflammatory multicomponent natural preparation API-NORM^® NEO combines the restoration of the depleted potential of the cell's protective mechanisms with the effects of suppressing unwanted increased proliferation and activation of the self-destruction function of defective cells, bringing these functions to the physiological norm.

A general property of multicomponent natural preparations used in the form of suppositories is the normalization of the sensitivity of many regulatory systems of the cell at once, which were disturbed due to long-term irritation by factors affecting cells. This is ensured by the simultaneous impact on a wide range of different signaling and biochemical cascades by a variety of biological substances that have entered the cells directly at the site of application, bypassing complete or partial destruction in the gastrointestinal tract and liver. This approach is effective especially in chronic inflammations, when cells or tissues, which did not have the opportunity to independently cope with a long-term damaging effect, almost stop responding to it. The combination of nutrition of cells with microelements with a moderate antibacterial action of a non-antibiotic nature leads to the normalization of microbiocenosis without destroying normal microflora.

Thanks to the complex of properties, the natural preparation "API-NORM^® NEO rectal suppositories" activates local immunity, relieves inflammation, saturates cells with the necessary trace elements, suppresses excessive cell division, which creates the necessary conditions for effective treatment of chronic inflammation and neoplasia of the pelvic organs.

• suppression of excess proliferation;
• detoxification of cell decay products and other toxins;
• local replenishment of depleted reserves of microelements and macromolecules necessary to ensure cellular protection systems;
• restoration and normalization of immune properties of cells and tissues;
• removal of excess load from antioxidant and other protective mechanisms of the cell;
• destruction of the protective biofilm of bacteria, which ensures their therapeutic availability;
• creating an antiseptic semi-penetrating wax coating on the surface of the wound and nerve endings;
• relief of inflammation and swelling with a moderate analgesic effect;
• deep penetration of active substances reaches almost all organs of the small pelvis;
• normalization of the microbiocenosis of the hollow organs of the small pelvis;
• reduces the effect of factors that stimulate cell regeneration, which prevents the development of precancerous conditions and prevents neoplasia recurrences.

• for the prevention and prevention of chronic inflammation, the development of neoplastic processes in the organs of the small pelvis, strengthening of the local immune response, initiation of apoptosis (death) of changed cells;
• in complex therapy as an adjunct before surgical interventions and after antitumor therapy to reduce local intoxication, prevent complications, create conditions for "safe" physiological healing of postoperative wounds with inhibition of excessive proliferation; restoration of immune protection and prevention of relapses;
• in palliative care as a local anti-edematous, anti-inflammatory and analgesic agent with the effect of inhibiting the growth, malignization and spread of neoplasms.

In proctology: with adenomatous polyps, erosions, chronic inflammatory processes, with the threat of occurrence and development of neoplastic changes in the rectum and sigmoid colon.

In urology: with chronic inflammatory processes that threaten the development of neoplastic changes in the prostate gland, urinary system, seminal vesicles and other pelvic organs.

In gynecology: with chronic inflammatory processes and neoplastic changes of the uterus, fallopian tubes and ovaries.

Do not use during pregnancy.

During the treatment period, breastfeeding should be stopped.

Use with caution in case of severe liver function disorders, individual hypersensitivity to any of the components of the drug.

During the treatment, it is advisable to refrain from traumatic actions, consumption of spicy food and alcoholic beverages. Alcohol intoxication destroys the achieved therapeutic effect.

General provisions. Before using the drug, to improve absorption through the rectum of active substances, it is advisable to empty the intestines. The suppository is inserted into the rectum at the depth of the index finger. After the introduction of the suppository, it is recommended to lie down for 15 minutes on the left or right side. If the mucous membrane is damaged, a burning sensation may be felt for 3-5 minutes in the first days of use.

For chronic inflammatory processes and neoplastic changes in the organs of the small pelvis, 1 suppository is used at night for 10-15 days. Depending on the course of the disease and the doctor's recommendation, there may be up to three such courses. The break between courses should be 5 days.

In the period of rehabilitation after radiation and chemotherapy API-NORM^® NEO is applied on the second day after the end of the radiation courses, and on the 7-10th day after the end of the courses chemotherapy 1 suppository at night for 10-15 days. The duration of use is determined by the dynamics of rehabilitation and the doctor's recommendation. Depending on the course of the disease and the doctor's recommendation, there may be up to three such courses. The break between courses should be 5 days.

In the preoperative period API-NORM^® NEO is used to reduce inflammatory processes and increase tumor resectability. For this purpose, 2 suppositories are used at night for 5-10 days. To ensure good visibility of the operating field, the use of suppositories should be stopped 2-3 days before the operation.

In the postoperative period on the second day after surgery, 1-2 suppositories per day are used on the pelvic organs to relieve swelling, prevent inflammation, the occurrence of sepsis, anesthetize and suppress excess proliferation. The duration of use is determined by the dynamics of recovery processes. After 10-15 days of reception, it is necessary to take a break for 5 days and continue further use according to the doctor's recommendation.

Peculiarities of application in gynecology to increase the therapeutic accessibility of the uterus, fallopian tubes and ovaries vaginal suppositories API-NORM are used simultaneously^® NEO – vaginal and rectal suppositories API-NORM< sup>® NEO – rectally 1 suppository of each type at night.
The course of double use is 10-15 days. The break between courses should be 5 days. The decision on further use is made based on the results of the assessment of the dynamics of changes and the doctor's recommendation.

For palliative care and in cases of impossibility or impracticality of further full-fledged cytotoxic therapy and surgical intervention, suppositories API-NORM^® NEO are used to restrain the development of the tumor process, remove inflammation, pain relief, improvement of the general condition. It can be used both episodically and in courses lasting 10-15 days, 2 suppositories per day. The break between courses should be 5 days.

In order to prevent the development of relapses of chronic inflammation and neoplastic changes in the organs of the small pelvis, in patients who have had an oncological incident or a genetic predisposition, it is recommended to carry out every three months for two years, and especially in the autumn and spring periods preventive courses of 1 suppository at night, every day or every other day, for 10-15 days. If the condition worsens, it is possible to conduct additional maintenance courses of 1 suppository per day for 5-10 days per month.

General weakness, dizziness, nausea, joint pain, gastrointestinal disorders, burning and itching in the rectum are possible. When similar symptoms appear, the drug intake is reduced to 1 suppository per day for 3-5 days. After that you should continue the course. If the above or other side effects that have not been observed before last for more than 3-5 days, you should stop taking the drug and consult a doctor.

Intensification of the specified side effects is possible.

The drug should be stored from 0° to +25° C in a dark place inaccessible to children.